Antineutrophil cytoplasmic antibodies and associated diseases: A review of the clinical and laboratory features

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Antineutrophil cytoplasmic antibodies and associated diseases: a review of the clinical and laboratory features.

There have been a number of recent advances in this field. First, the "International Consensus Statement on Testing and Reporting of Antineutrophil Cytoplasmic Antibodies (ANCA)" has been developed to optimize ANCA testing. It requires that all sera are tested by indirect immunofluorescent (IIF) examination of normal peripheral blood neutrophils and, where there is positive fluorescence, in enz...

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Antineutrophil Cytoplasmic Antibodies Associated With Infective Endocarditis

To determine the prevalence of antineutrophil cytoplasmic antibodies (ANCA) in patients with infective endocarditis (IE) in internal medicine; and to compare clinical and biochemical features and outcome between patients exhibiting IE with and without ANCA.Fifty consecutive patients with IE underwent ANCA testing. The medical records of these patients were reviewed.Of the 50 patients with IE, 1...

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Antineutrophil cytoplasmic antibodies.

Antineutrophil cytoplasmic antibodies (ANCA) are predominantly IgG autoantibodies directed against constituents of primary granules of neutrophils and monocytes lysosomes. Although several antigenic targets have been identified, those ANCA directed to proteinase 3 or myeloperoxidase are clinically relevant, whereas the importance of other ANCA remains unknown. Both are strongly associated with ...

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ژورنال

عنوان ژورنال: Kidney International

سال: 2000

ISSN: 0085-2538

DOI: 10.1046/j.1523-1755.2000.057003846.x